Transforming growth factor activating kinase 1 regulates extracellular matrix degrading enzymes and pain-related molecule expression following tumor necrosis factor-α stimulation of synovial cells: an in vitro study

Transforming growth factor activating kinase 1 regulates extracellular matrix degrading enzymes and pain-related molecule expression following tumor necrosis factor-α stimulation of synovial cells: an in vitro study

Abstract Background Recent studies have suggested that the tumor necrosis factor-α (TNF-α) pathway is a potential target for the management of osteoarthritis (OA). Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) is essential in several cytokine-mediated cascades, including the TNF-α, in...

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Bibliographic Details
Main Authors: Kentaro Uchida, Shotaro Takano, Toshihide Matsumoto, Naoshige Nagura, Gen Inoue, Makoto Itakura, Masayuki Miyagi, Jun Aikawa, Dai Iwase, Atsushi Minatani, Hisako Fujimaki, Masashi Takaso
Format: Article
Language:English
Published: BMC 2017-07-01
Series:BMC Musculoskeletal Disorders
Subjects:
Synovium
TGF-beta-activated kinase 1
Tumor necrosis factor-alpha
Matrix metalloproteinase 3
A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4
Cyclooxygenase-2
Online Access:http://link.springer.com/article/10.1186/s12891-017-1648-4

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http://link.springer.com/article/10.1186/s12891-017-1648-4

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