Development and Characterisation of an in vitro Model of Wallerian Degeneration

Development and Characterisation of an in vitro Model of Wallerian Degeneration

Following peripheral nerve injury, a sequence of events termed Wallerian degeneration (WD) takes place at the distal stump in order to allow the regenerating axons to grow back toward the target organs. Schwann cells (SCs) play a lead role in this by initiating the inflammatory response attracting m...

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Bibliographic Details
Main Authors: Heba Elsayed, Alessandro Faroni, Mohammad R. Ashraf, Judith Osuji, Lydia Wunderley, Ling Zhang, Hesham Elsobky, Mohamed Mansour, Ashraf S. Zidan, Adam J. Reid
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Wallerian degeneration
Schwann cells
nerve injury
myelin degradation
neurotrophic factors
in vitro model
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00784/full

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https://www.frontiersin.org/article/10.3389/fbioe.2020.00784/full

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