Crystal structure of the Lin28-interacting module of human terminal uridylyltransferase that regulates let-7 expression
Terminal uridylyltransferase 4/7 (TUT4/7) binds to Lin28 and modifies let-7 precursor (pre-let-7) to regulate cell differentiation and proliferation. Here the authors report the crystal structure of the N-terminal Lin28-interacting module of TUT4, showing a role of the N-terminal zinc finger domain...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-04-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09966-5 |