Modeling of <i>LMNA</i>-Related Dilated Cardiomyopathy Using Human Induced Pluripotent Stem Cells

Modeling of <i>LMNA</i>-Related Dilated Cardiomyopathy Using Human Induced Pluripotent Stem Cells

Dilated cardiomyopathy (DCM) is one of the leading causes of heart failure and heart transplantation. A portion of familial DCM is due to mutations in the <i>LMNA</i> gene encoding the nuclear lamina proteins lamin A and C and without adequate treatment these patients have a poor prognos...

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Bibliographic Details
Main Authors: Disheet Shah, Laura Virtanen, Chandra Prajapati, Mostafa Kiamehr, Josef Gullmets, Gun West, Joose Kreutzer, Mari Pekkanen-Mattila, Tiina Heliö, Pasi Kallio, Pekka Taimen, Katriina Aalto-Setälä
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cells
Subjects:
dilated cardiomyopathy
<i>LMNA</i>
Lamin A/C
induced pluripotent stem cell
hypoxia
microelectrode array and calcium imaging
Online Access:https://www.mdpi.com/2073-4409/8/6/594

Internet

https://www.mdpi.com/2073-4409/8/6/594

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