Osteopontin N-Terminal Function in an Abdominal Aortic Aneurysm From Apolipoprotein E-Deficient Mice

Osteopontin N-Terminal Function in an Abdominal Aortic Aneurysm From Apolipoprotein E-Deficient Mice

The cleavage of osteopontin (OPN) by thrombin results in an N-terminal fragment (OPN-N), which exposes a cryptic integrin-binding motif that promotes the adherence of cells, and plays a proinflammatory role. However, the effect of OPN-N on abdominal aortic aneurysm (AAA) remains unknown. The aim of...

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Bibliographic Details
Main Authors: Hongyang Liu, Ying Zhang, Wei Song, Yancui Sun, Yinong Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
osteopontin N-terminal
abdominal aortic aneurysm
pyroptosis
ApoE-/- mice
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.681790/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.681790/full

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