Negative inotropic and dromotropic actions of SiO2 nanoparticles on isolated rat hearts: Effects on Na+ and Ca2+ currents

Negative inotropic and dromotropic actions of SiO2 nanoparticles on isolated rat hearts: Effects on Na+ and Ca2+ currents

Context: SiO2 nanoparticles (NP) are widely used in the industry and in varied biotechnological and medical applications. However, epidemiological studies suggest that pollution with fine particles (in which silica is an inorganic component) may increase morbidity and mortality from cardiovascular d...

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Bibliographic Details
Main Authors: Julio Alvarez-Collazo, Loipa Galán-Martínez, Alicia Fleites-Vazquez, Alicia Sánchez-Linde, Karel Talavera-Pérez, Julio L. Alvarez
Format: Article
Language:English
Published: Academic Association of Pharmaceutical Sciences from Antofagasta (ASOCIFA) 2016-12-01
Series:Journal of Pharmacy & Pharmacognosy Research
Subjects:
calcium channels
heart
nanoparticles
patch-clamp
silica
sodium channels
Online Access:http://jppres.com/jppres/pdf/vol4/jppres16.162_4.6.217.pdf

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http://jppres.com/jppres/pdf/vol4/jppres16.162_4.6.217.pdf

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