Ca2+ current facilitation is CaMKII-dependent and has arrhythmogenic consequences

The cardiac voltage gated Ca2+ current (ICa) is critical to the electrophysiological properties, excitation-contraction coupling, mitochondrial energetics and transcriptional regulation in heart. Thus, it is not surprising that cardiac ICa is regulated by numerous pathways. This review will focus on...

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Bibliographic Details
Main Authors: Donald M Bers, Stefano eMorotti
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00144/full