Variable prediction accuracy of polygenic scores within an ancestry group

Variable prediction accuracy of polygenic scores within an ancestry group

Fields as diverse as human genetics and sociology are increasingly using polygenic scores based on genome-wide association studies (GWAS) for phenotypic prediction. However, recent work has shown that polygenic scores have limited portability across groups of different genetic ancestries, restrictin...

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Bibliographic Details
Main Authors: Hakhamanesh Mostafavi, Arbel Harpak, Ipsita Agarwal, Dalton Conley, Jonathan K Pritchard, Molly Przeworski
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
human genetics
GWAS
polygenic scores
trait prediction
portability
Online Access:https://elifesciences.org/articles/48376

Internet

https://elifesciences.org/articles/48376

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