Lentiviral delivery of combinatorial CAR/CRISPRi circuit into human primary T cells is enhanced by TBK1/IKKɛ complex inhibitor BX795

Lentiviral delivery of combinatorial CAR/CRISPRi circuit into human primary T cells is enhanced by TBK1/IKKɛ complex inhibitor BX795

Abstract Background Adoptive transfer of engineered immune cells is a promising strategy for cancer treatment. However, low transduction efficiency particularly when large payload lentiviral vectors are used on primary T cells is a limitation for the development of cell therapy platforms that includ...

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Bibliographic Details
Main Authors: Lingyu Li, Yuan Gao, Richa Srivastava, Wei Wang, Qinghui Xiong, Zhiming Fang, Alejandra Pelayo, Carolyn Denson, Angshumala Goswami, Rona Harari-Steinfeld, Zhifen Yang, Lihong Weng, Lei Stanley Qi, Francesco M. Marincola
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Journal of Translational Medicine
Subjects:
BX795
Lentiviral transduction
T cell engineering
CAR-T
CRISPRi
Online Access:http://link.springer.com/article/10.1186/s12967-020-02526-2

Internet

http://link.springer.com/article/10.1186/s12967-020-02526-2

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