A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction
The full extent of the genetic basis for hearing impairment is unknown. Here, as part of the International Mouse Phenotyping Consortium, the authors perform a hearing loss screen in 3006 mouse knockout strains and identify 52 new candidate genes for genetic hearing loss.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2017-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00595-4 |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Michael R. Bowl Michelle M. Simon Neil J. Ingham Simon Greenaway Luis Santos Heather Cater Sarah Taylor Jeremy Mason Natalja Kurbatova Selina Pearson Lynette R. Bower Dave A. Clary Hamid Meziane Patrick Reilly Osamu Minowa Lois Kelsey The International Mouse Phenotyping Consortium Glauco P. Tocchini-Valentini Xiang Gao Allan Bradley William C. Skarnes Mark Moore Arthur L. Beaudet Monica J. Justice John Seavitt Mary E. Dickinson Wolfgang Wurst Martin Hrabe de Angelis Yann Herault Shigeharu Wakana Lauryl M. J. Nutter Ann M. Flenniken Colin McKerlie Stephen A. Murray Karen L. Svenson Robert E. Braun David B. West K. C. Kent Lloyd David J. Adams Jacqui White Natasha Karp Paul Flicek Damian Smedley Terrence F. Meehan Helen E. Parkinson Lydia M. Teboul Sara Wells Karen P. Steel Ann-Marie Mallon Steve D. M. Brown |
| spellingShingle |
Michael R. Bowl Michelle M. Simon Neil J. Ingham Simon Greenaway Luis Santos Heather Cater Sarah Taylor Jeremy Mason Natalja Kurbatova Selina Pearson Lynette R. Bower Dave A. Clary Hamid Meziane Patrick Reilly Osamu Minowa Lois Kelsey The International Mouse Phenotyping Consortium Glauco P. Tocchini-Valentini Xiang Gao Allan Bradley William C. Skarnes Mark Moore Arthur L. Beaudet Monica J. Justice John Seavitt Mary E. Dickinson Wolfgang Wurst Martin Hrabe de Angelis Yann Herault Shigeharu Wakana Lauryl M. J. Nutter Ann M. Flenniken Colin McKerlie Stephen A. Murray Karen L. Svenson Robert E. Braun David B. West K. C. Kent Lloyd David J. Adams Jacqui White Natasha Karp Paul Flicek Damian Smedley Terrence F. Meehan Helen E. Parkinson Lydia M. Teboul Sara Wells Karen P. Steel Ann-Marie Mallon Steve D. M. Brown A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction Nature Communications |
| author_facet |
Michael R. Bowl Michelle M. Simon Neil J. Ingham Simon Greenaway Luis Santos Heather Cater Sarah Taylor Jeremy Mason Natalja Kurbatova Selina Pearson Lynette R. Bower Dave A. Clary Hamid Meziane Patrick Reilly Osamu Minowa Lois Kelsey The International Mouse Phenotyping Consortium Glauco P. Tocchini-Valentini Xiang Gao Allan Bradley William C. Skarnes Mark Moore Arthur L. Beaudet Monica J. Justice John Seavitt Mary E. Dickinson Wolfgang Wurst Martin Hrabe de Angelis Yann Herault Shigeharu Wakana Lauryl M. J. Nutter Ann M. Flenniken Colin McKerlie Stephen A. Murray Karen L. Svenson Robert E. Braun David B. West K. C. Kent Lloyd David J. Adams Jacqui White Natasha Karp Paul Flicek Damian Smedley Terrence F. Meehan Helen E. Parkinson Lydia M. Teboul Sara Wells Karen P. Steel Ann-Marie Mallon Steve D. M. Brown |
| author_sort |
Michael R. Bowl |
| title |
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction |
| title_short |
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction |
| title_full |
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction |
| title_fullStr |
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction |
| title_full_unstemmed |
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction |
| title_sort |
large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-10-01 |
| description |
The full extent of the genetic basis for hearing impairment is unknown. Here, as part of the International Mouse Phenotyping Consortium, the authors perform a hearing loss screen in 3006 mouse knockout strains and identify 52 new candidate genes for genetic hearing loss. |
| url |
https://doi.org/10.1038/s41467-017-00595-4 |
| work_keys_str_mv |
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doaj-c71478f2406844f6901b4df53eb1c02c2021-05-11T07:54:45ZengNature Publishing GroupNature Communications2041-17232017-10-018111110.1038/s41467-017-00595-4A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunctionMichael R. Bowl0Michelle M. Simon1Neil J. Ingham2Simon Greenaway3Luis Santos4Heather Cater5Sarah Taylor6Jeremy Mason7Natalja Kurbatova8Selina Pearson9Lynette R. Bower10Dave A. Clary11Hamid Meziane12Patrick Reilly13Osamu Minowa14Lois Kelsey15The International Mouse Phenotyping ConsortiumGlauco P. Tocchini-Valentini16Xiang Gao17Allan Bradley18William C. Skarnes19Mark Moore20Arthur L. Beaudet21Monica J. Justice22John Seavitt23Mary E. Dickinson24Wolfgang Wurst25Martin Hrabe de Angelis26Yann Herault27Shigeharu Wakana28Lauryl M. J. Nutter29Ann M. Flenniken30Colin McKerlie31Stephen A. Murray32Karen L. Svenson33Robert E. Braun34David B. West35K. C. Kent Lloyd36David J. Adams37Jacqui White38Natasha Karp39Paul Flicek40Damian Smedley41Terrence F. Meehan42Helen E. Parkinson43Lydia M. Teboul44Sara Wells45Karen P. Steel46Ann-Marie Mallon47Steve D. M. Brown48Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre)Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre)King’s College LondonMedical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre)Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre)Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre)Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre)European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome CampusEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome CampusThe Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusMouse Biology Program, University of CaliforniaMouse Biology Program, University of CaliforniaCELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS)CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS)RIKEN BioResource CenterThe Centre for PhenogenomicsMonterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and NeurobiologySKL of Pharmaceutical Biotechnology and Model Animal Research Center, Collaborative Innovation Center for Genetics and Development, Nanjing Biomedical Research Institute, Nanjing UniversityThe Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusThe Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusIMPCDepartment of Molecular and Human Genetics, Baylor College of MedicineThe Centre for PhenogenomicsDepartment of Molecular and Human Genetics, Baylor College of MedicineDepartment of Molecular Physiology and Biophysics, Baylor College of MedicineInstitute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbHGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbHCELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS)RIKEN BioResource CenterThe Centre for PhenogenomicsThe Centre for PhenogenomicsThe Centre for PhenogenomicsThe Jackson LaboratoryThe Jackson LaboratoryThe Jackson LaboratoryChildrens’ Hospital Oakland Research InstituteMouse Biology Program, University of CaliforniaThe Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusThe Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusThe Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome CampusQueen Mary University of LondonEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome CampusEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome CampusMedical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre)Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre)King’s College LondonMedical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre)Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre)The full extent of the genetic basis for hearing impairment is unknown. Here, as part of the International Mouse Phenotyping Consortium, the authors perform a hearing loss screen in 3006 mouse knockout strains and identify 52 new candidate genes for genetic hearing loss.https://doi.org/10.1038/s41467-017-00595-4 |