Acquisition of clofazimine resistance following bedaquiline treatment for multidrug-resistant tuberculosis

Acquisition of clofazimine resistance following bedaquiline treatment for multidrug-resistant tuberculosis

Objectives: We described the prevalence of clofazimine (CFZ) resistance in a multidrug-resistant tuberculosis (MDR-TB) cohort in China. We also aimed to identify dynamic changes in CFZ susceptibility and its molecular mechanism after exposure to bedaquiline (BDQ) and/or CFZ. Methods: The experimenta...

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Bibliographic Details
Main Authors: Yuhong Liu, Jingtao Gao, Jian Du, Wei Shu, Lu Wang, Yufeng Wang, Zhongtan Xue, Liang Li, Shaofa Xu, Yu Pang
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:International Journal of Infectious Diseases
Subjects:
tuberculosis
bedaquiline
clofazimine
acquisition resistance
multidrug-resistant
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971220322852

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http://www.sciencedirect.com/science/article/pii/S1201971220322852

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