Stress-induced microglial activation occurs through β-adrenergic receptor: noradrenaline as a key neurotransmitter in microglial activation

Abstract Background The involvement of microglia in neuroinflammatory responses has been extensively demonstrated. Recent animal studies have shown that exposure to either acute or chronic stress induces robust microglial activation in the brain. In the present study, we investigated the underlying...

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Bibliographic Details
Main Authors: Shuei Sugama, Takato Takenouchi, Makoto Hashimoto, Hisayuki Ohata, Yasuhiro Takenaka, Yoshihiko Kakinuma
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Neuroinflammation
Subjects:
CNS
Online Access:https://doi.org/10.1186/s12974-019-1632-z