Potential applications of microfluidics based blood brain barrier (BBB)-on-chips for in vitro drug development

Potential applications of microfluidics based blood brain barrier (BBB)-on-chips for in vitro drug development

The human blood-brain barrier (BBB) is a complex multi-dimensional reticular barrier system composed of cerebral microvascular endothelial cells, pericytes, astrocytes and a variety of neurons. The conventional in vitro cell culture model fails to truly present the dynamic hemodynamics of BBB and th...

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Bibliographic Details
Main Authors: Xiaobo Wang, Ya Hou, Xiaopeng Ai, Jiayi Sun, Binjie Xu, Xianli Meng, Yi Zhang, Sanyin Zhang
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Microfluidics
BBB-on-chips
Screening active ingredients
Effectiveness evaluation
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220310155

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http://www.sciencedirect.com/science/article/pii/S0753332220310155

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