Flagellin shifts 3D bronchospheres towards mucus hyperproduction

Flagellin shifts 3D bronchospheres towards mucus hyperproduction

Abstract Cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are associated with acute and chronic bacterial infections of the lung. Excessive differentiation of basal cells to mucus-producing goblet cells can result in mucus hyperproduction and loss of mucociliary clearance in the...

Full description

Bibliographic Details
Main Authors: Richard F. Sprott, Felix Ritzmann, Frank Langer, Yiwen Yao, Christian Herr, Yvonne Kohl, Thomas Tschernig, Robert Bals, Christoph Beisswenger
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Respiratory Research
Subjects:
Organoids
Bronchospheres
Mucus
PAMPs
Flagellin
Online Access:http://link.springer.com/article/10.1186/s12931-020-01486-x

Internet

http://link.springer.com/article/10.1186/s12931-020-01486-x

Similar Items