Flagellin shifts 3D bronchospheres towards mucus hyperproduction
Abstract Cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are associated with acute and chronic bacterial infections of the lung. Excessive differentiation of basal cells to mucus-producing goblet cells can result in mucus hyperproduction and loss of mucociliary clearance in the...
Main Authors: | Richard F. Sprott, Felix Ritzmann, Frank Langer, Yiwen Yao, Christian Herr, Yvonne Kohl, Thomas Tschernig, Robert Bals, Christoph Beisswenger |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-08-01
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Series: | Respiratory Research |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12931-020-01486-x |
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