Target Identification of an Antimalarial Oxaborole Identifies AN13762 as an Alternative Chemotype for Targeting CPSF3 in Apicomplexan Parasites

Target Identification of an Antimalarial Oxaborole Identifies AN13762 as an Alternative Chemotype for Targeting CPSF3 in Apicomplexan Parasites

Summary: Boron-containing compounds represent a promising class of molecules with proven efficacy against a wide range of pathogens, including apicomplexan parasites. Following lead optimization, the benzoxaborole AN13762 was identified as a preclinical candidate against the human malaria parasite,...

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Bibliographic Details
Main Authors: Valeria Bellini, Christopher Swale, Marie-Pierre Brenier-Pinchart, Tiffany Pezier, Sonia Georgeault, Fabrice Laurent, Mohamed-Ali Hakimi, Alexandre Bougdour
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:iScience
Subjects:
Molecular Biology
Molecular Medicine
Microbiology
Microbiology Parasite
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220310683

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http://www.sciencedirect.com/science/article/pii/S2589004220310683

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