Genomic analyses of early responses to radiation in glioblastoma reveal new alterations at transcription, splicing, and translation levels

Abstract High-dose radiation is the main component of glioblastoma therapy. Unfortunately, radio-resistance is a common problem and a major contributor to tumor relapse. Understanding the molecular mechanisms driving response to radiation is critical for identifying regulatory routes that could be t...

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Bibliographic Details
Main Authors: Saket Choudhary, Suzanne C. Burns, Hoda Mirsafian, Wenzheng Li, Dat T. Vo, Mei Qiao, Xiufen Lei, Andrew D. Smith, Luiz O. Penalva
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-65638-1