Sphingolipid Metabolism Is Dysregulated at Transcriptomic and Metabolic Levels in the Spinal Cord of an Animal Model of Amyotrophic Lateral Sclerosis

Sphingolipid Metabolism Is Dysregulated at Transcriptomic and Metabolic Levels in the Spinal Cord of an Animal Model of Amyotrophic Lateral Sclerosis

Lipid metabolism is drastically dysregulated in amyotrophic lateral sclerosis and impacts prognosis of patients. Animal models recapitulate alterations in the energy metabolism, including hypermetabolism and severe loss of adipose tissue. To gain insight into the molecular mechanisms underlying dise...

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Bibliographic Details
Main Authors: Alexandre Henriques, Vincent Croixmarie, Alexandra Bouscary, Althéa Mosbach, Céline Keime, Claire Boursier-Neyret, Bernard Walter, Michael Spedding, Jean-Philippe Loeffler
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
amyotrophic lateral sclerosis
RNA-sequencing
transcriptomics
metabolomics
SOD1 mice
sphingolipids
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00433/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00433/full

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