LUMAN/CREB3 Plays a Dual Role in Stress Responses as a Cofactor of the Glucocorticoid Receptor and a Regulator of Secretion

LUMAN/CREB3 Plays a Dual Role in Stress Responses as a Cofactor of the Glucocorticoid Receptor and a Regulator of Secretion

LUMAN/CREB3, originally identified through its interaction with a cell cycle regulator HCFC1, is a transcription factor involved in the unfolded protein response during endoplasmic reticulum stress. Previously using gene knockout mouse models, we have shown that LUMAN modulates the glucocorticoid (G...

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Bibliographic Details
Main Authors: Jenna Penney, Tiegh Taylor, Neil MacLusky, Ray Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
glucocorticoid receptor
LUMAN/CREB3
hypothalamic pituitary adrenal axis
stress
secretion
nuclear receptor co-factor
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00352/full

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00352/full

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