Vitamin D Receptor Mediates a Myriad of Biological Actions Dependent on Its 1,25‐Dihydroxyvitamin D Ligand: Distinct Regulatory Themes Revealed by Induction of Klotho and Fibroblast Growth Factor‐23

Vitamin D Receptor Mediates a Myriad of Biological Actions Dependent on Its 1,25‐Dihydroxyvitamin D Ligand: Distinct Regulatory Themes Revealed by Induction of Klotho and Fibroblast Growth Factor‐23

ABSTRACT The hormonal vitamin D metabolite, 1,25‐dihydroxyvitamin D [1,25(OH)2D], produced in kidney, acts in numerous end organs via the nuclear vitamin D receptor (VDR) to trigger molecular events that orchestrate bone mineral homeostasis. VDR is a ligand‐controlled transcription factor that oblig...

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Bibliographic Details
Main Authors: Mark R Haussler, Sarah Livingston, Zhela L Sabir, Carol A Haussler, Peter W Jurutka
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:JBMR Plus
Subjects:
PTH/VITAMIN D/FGF23
OSTEOBLASTS
OSTEOCYTES
TRANSCRIPTION FACTORS
BONE REMODELING/MOLECULAR PATHWAYS
Online Access:https://doi.org/10.1002/jbm4.10432

Internet

https://doi.org/10.1002/jbm4.10432

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