Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration.

Raf Kinase Inhibitory Protein (RKIP, also PEBP1), a member of the Phosphatidylethanolamine Binding Protein family, negatively regulates growth factor signaling by the Raf/MAP kinase pathway. Since an organic compound, locostatin, was reported to bind RKIP and inhibit cell migration by a Raf-dependen...

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Bibliographic Details
Main Authors: Anne N Shemon, Eva M Eves, Matthew C Clark, Gary Heil, Alexey Granovsky, Lingchun Zeng, Akira Imamoto, Shohei Koide, Marsha Rich Rosner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2696091?pdf=render