Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression

Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression

Polycomb repressive complexes modify histones but it is unclear how changes in chromatin states alter kinetics of transcription. Here, the authors use single-cell RNAseq and ChIPseq to find that actively transcribed genes with Polycomb marks have greater cell-to-cell variation in expression.

Bibliographic Details
Main Authors: Gozde Kar, Jong Kyoung Kim, Aleksandra A. Kolodziejczyk, Kedar Nath Natarajan, Elena Torlai Triglia, Borbala Mifsud, Sarah Elderkin, John C. Marioni, Ana Pombo, Sarah A. Teichmann
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00052-2

Internet

https://doi.org/10.1038/s41467-017-00052-2

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