Immunodominance of Epitopes and Protective Efficacy of HI Antigen Are Differentially Altered Using Different Adjuvants in a Mouse Model of Staphylococcus aureus Bacteremia

Immunodominance of Epitopes and Protective Efficacy of HI Antigen Are Differentially Altered Using Different Adjuvants in a Mouse Model of Staphylococcus aureus Bacteremia

HI, a fusion protein that consists of the alpha-toxin (Hla) and the N2 domain of iron surface determinant B (IsdB), is one of the antigens in the previously reported S. aureus vaccine rFSAV and has already entered phase II clinical trials. Previous studies revealed that HI is highly immunogenic in b...

Full description

Bibliographic Details
Main Authors: Zhifu Chen, Qiang Gou, Qingshan Xiong, Lianli Duan, Yue Yuan, Jiang Zhu, Jintao Zou, Longlong Chen, Haiming Jing, Xiaoli Zhang, Ping Luo, Hao Zeng, Quanming Zou, Zhuo Zhao, Jinyong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
Staphylococcus aureus
immunodominant epitope
antibody
adjuvants
bacteremia
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.684823/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.684823/full

Similar Items