Genetic Regulation of Guanylate-Binding Proteins 2b and 5 during Leishmaniasis in Mice

Genetic Regulation of Guanylate-Binding Proteins 2b and 5 during Leishmaniasis in Mice

Interferon-induced GTPases [guanylate-binding proteins (GBPs)] play an important role in inflammasome activation and mediate innate resistance to many intracellular pathogens, but little is known about their role in leishmaniasis. We therefore studied expression of Gbp2b/Gbp1 and Gbp5 mRNA in skin,...

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Bibliographic Details
Main Authors: Yahya Sohrabi, Valeryia Volkova, Tatyana Kobets, Helena Havelková, Imtissal Krayem, Martina Slapničková, Peter Demant, Marie Lipoldová
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
Leishmania major
recombinant congenic strains
guanylate-binding proteins
a hidden inflammation
genetic control
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00130/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00130/full

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