The effect of injected dose on localized tumor accumulation and cardiac uptake of doxorubicin in a Vx2 rabbit tumor model using MR-HIFU mild hyperthermia and thermosensitive liposomes

The effect of injected dose on localized tumor accumulation and cardiac uptake of doxorubicin in a Vx2 rabbit tumor model using MR-HIFU mild hyperthermia and thermosensitive liposomes

Purpose When doxorubicin (DOX) is administered via lyso-thermosensitive liposomes (LTLD), mild hyperthermia enhances localized delivery to heated vs. unheated tumors. The optimal LTLD dose and the impact of different doses on systemic drug distribution are unknown. Materials and methods: In this stu...

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Bibliographic Details
Main Authors: Bingbing Cheng, Chenchen Bing, Robert M. Staruch, Sumbul Shaikh, Michelle Wodzak Staruch, Debra Szczepanski, Noelle S. Williams, Theodore W. Laetsch, Rajiv Chopra
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:International Journal of Hyperthermia
Subjects:
targeted drug delivery
thermosensitive liposomal doxorubicin
dose
mr-guided high intensity focused ultrasound
mild hyperthermia
Online Access:http://dx.doi.org/10.1080/02656736.2020.1812737

Internet

http://dx.doi.org/10.1080/02656736.2020.1812737

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