Escaping Host Factor PI4KB Inhibition: Enterovirus Genomic RNA Replication in the Absence of Replication Organelles

Escaping Host Factor PI4KB Inhibition: Enterovirus Genomic RNA Replication in the Absence of Replication Organelles

Enteroviruses reorganize cellular endomembranes into replication organelles (ROs) for genome replication. Although enterovirus replication depends on phosphatidylinositol 4-kinase type IIIβ (PI4KB), its role, and that of its product, phosphatidylinositol 4-phosphate (PI4P), is only partially underst...

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Bibliographic Details
Main Authors: Charlotte E. Melia, Hilde M. van der Schaar, Heyrhyoung Lyoo, Ronald W.A.L. Limpens, Qian Feng, Maryam Wahedi, Gijs J. Overheul, Ronald P. van Rij, Eric J. Snijder, Abraham J. Koster, Montserrat Bárcena, Frank J.M. van Kuppeveld
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Cell Reports
Subjects:
enterovirus
replication organelles
PI4P
phosphatidylinositol 4-kinase type IIIβ
polyprotein processing
innate immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717313736

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http://www.sciencedirect.com/science/article/pii/S2211124717313736

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