Inferring protein modulation from gene expression data using conditional mutual information.

Systematic, high-throughput dissection of causal post-translational regulatory dependencies, on a genome wide basis, is still one of the great challenges of biology. Due to its complexity, however, only a handful of computational algorithms have been developed for this task. Here we present CINDy (C...

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Bibliographic Details
Main Authors: Federico M Giorgi, Gonzalo Lopez, Jung H Woo, Brygida Bisikirska, Andrea Califano, Mukesh Bansal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4196905?pdf=render