Alternative Splicing in the Hippo Pathway—Implications for Disease and Potential Therapeutic Targets

Alternative splicing is a well-studied gene regulatory mechanism that produces biological diversity by allowing the production of multiple protein isoforms from a single gene. An involvement of alternative splicing in the key biological signalling Hippo pathway is emerging and offers new therapeutic...

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Main Authors:	Sean Porazinski, Michael Ladomery
Format:	Article
Language:	English
Published:	MDPI AG 2018-03-01
Series:	Genes
Subjects:	Hippo pathway alternative splicing yes-associated protein splice-switching oligonucleotides gene therapy
Online Access:	http://www.mdpi.com/2073-4425/9/3/161

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spelling	doaj-c75de1b1b17c4d2fa4fdc228697629292020-11-24T21:04:47ZengMDPI AGGenes2073-44252018-03-019316110.3390/genes9030161genes9030161Alternative Splicing in the Hippo Pathway—Implications for Disease and Potential Therapeutic TargetsSean Porazinski0Michael Ladomery1Faculty of Health and Applied Sciences, University of the West of England, Frenchay Campus, Bristol BS16 1QY, UKFaculty of Health and Applied Sciences, University of the West of England, Frenchay Campus, Bristol BS16 1QY, UKAlternative splicing is a well-studied gene regulatory mechanism that produces biological diversity by allowing the production of multiple protein isoforms from a single gene. An involvement of alternative splicing in the key biological signalling Hippo pathway is emerging and offers new therapeutic avenues. This review discusses examples of alternative splicing in the Hippo pathway, how deregulation of these processes may contribute to disease and whether these processes offer new potential therapeutic targets.http://www.mdpi.com/2073-4425/9/3/161Hippo pathwayalternative splicingyes-associated proteinsplice-switching oligonucleotidesgene therapy
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sean Porazinski Michael Ladomery
spellingShingle	Sean Porazinski Michael Ladomery Alternative Splicing in the Hippo Pathway—Implications for Disease and Potential Therapeutic Targets Genes Hippo pathway alternative splicing yes-associated protein splice-switching oligonucleotides gene therapy
author_facet	Sean Porazinski Michael Ladomery
author_sort	Sean Porazinski
title	Alternative Splicing in the Hippo Pathway—Implications for Disease and Potential Therapeutic Targets
title_short	Alternative Splicing in the Hippo Pathway—Implications for Disease and Potential Therapeutic Targets
title_full	Alternative Splicing in the Hippo Pathway—Implications for Disease and Potential Therapeutic Targets
title_fullStr	Alternative Splicing in the Hippo Pathway—Implications for Disease and Potential Therapeutic Targets
title_full_unstemmed	Alternative Splicing in the Hippo Pathway—Implications for Disease and Potential Therapeutic Targets
title_sort	alternative splicing in the hippo pathway—implications for disease and potential therapeutic targets
publisher	MDPI AG
series	Genes
issn	2073-4425
publishDate	2018-03-01
description	Alternative splicing is a well-studied gene regulatory mechanism that produces biological diversity by allowing the production of multiple protein isoforms from a single gene. An involvement of alternative splicing in the key biological signalling Hippo pathway is emerging and offers new therapeutic avenues. This review discusses examples of alternative splicing in the Hippo pathway, how deregulation of these processes may contribute to disease and whether these processes offer new potential therapeutic targets.
topic	Hippo pathway alternative splicing yes-associated protein splice-switching oligonucleotides gene therapy
url	http://www.mdpi.com/2073-4425/9/3/161
work_keys_str_mv	AT seanporazinski alternativesplicinginthehippopathwayimplicationsfordiseaseandpotentialtherapeutictargets AT michaelladomery alternativesplicinginthehippopathwayimplicationsfordiseaseandpotentialtherapeutictargets
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Alternative Splicing in the Hippo Pathway—Implications for Disease and Potential Therapeutic Targets

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