Activation of SIRT1/PGC 1α/SIRT3 pathway by melatonin provides protection against mitochondrial dysfunction in isoproterenol induced myocardial injury

Activation of SIRT1/PGC 1α/SIRT3 pathway by melatonin provides protection against mitochondrial dysfunction in isoproterenol induced myocardial injury

Aims: Preventing mitochondrial dysfunction and enhancing mitochondrial health and biogenesis is a crucial therapeutic approach to ameliorate injury following acute myocardial infarction. Although the antioxidant role of melatonin against ischemia/reperfusion injury has been reported, the exact mecha...

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Bibliographic Details
Main Authors: Shamreen Naaz, Sanatan Mishra, Palash K. Pal, Aindrila Chattopadhyay, Asish R. Das, Debasish Bandyopadhyay
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Heliyon
Subjects:
Melatonin
Oxidative stress
SIRT1
SIRT3
PGC 1α
Isothermal titration calorimetry
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020320028

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http://www.sciencedirect.com/science/article/pii/S2405844020320028

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