Alpha-Tocotrienol Prevents Oxidative Stress-Mediated Post-Translational Cleavage of Bcl-xL in Primary Hippocampal Neurons

Alpha-Tocotrienol Prevents Oxidative Stress-Mediated Post-Translational Cleavage of Bcl-xL in Primary Hippocampal Neurons

B-cell lymphoma-extra large (Bcl-xL) is an anti-apoptotic member of the Bcl2 family of proteins, which supports neurite outgrowth and neurotransmission by improving mitochondrial function. During excitotoxic stimulation, however, Bcl-xL undergoes post-translational cleavage to ∆N-Bcl-xL, and accumul...

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Bibliographic Details
Main Authors: Han-A Park, Nelli Mnatsakanyan, Katheryn Broman, Abigail U. Davis, Jordan May, Pawel Licznerski, Kristi M. Crowe-White, Kimberly H. Lackey, Elizabeth A. Jonas
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:International Journal of Molecular Sciences
Subjects:
bcl-xl
∆n-bcl-xl
antioxidant
mitochondria
tocotrienol
Online Access:https://www.mdpi.com/1422-0067/21/1/220

Internet

https://www.mdpi.com/1422-0067/21/1/220

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