In Vitro Dissolution Study of Acetylsalicylic Acid and Clopidogrel Bisulfate Solid Dispersions: Validation of the RP-HPLC Method for Simultaneous Analysis

In Vitro Dissolution Study of Acetylsalicylic Acid and Clopidogrel Bisulfate Solid Dispersions: Validation of the RP-HPLC Method for Simultaneous Analysis

Solid dispersions were prepared via a solvent evaporation method, employing ethanol (96%, <i>v</i>/<i>v</i>) as solvent, with three different polymers as carrier: povidone, copovidone, and poloxamer 407. Previously developed reversed-phase HPLC (RP-HPLC) methods were modified...

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Bibliographic Details
Main Authors: Ehlimana Osmanović Omerdić, Larisa Alagić-Džambić, Marko Krstić, Maja Pašić-Kulenović, Jadranka Odović, Dragana Vasiljević
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Applied Sciences
Subjects:
clopidogrel bisulfate
acetylsalicylic acid
solid dispersion
dissolution
RP-HPLC
validation
Online Access:https://www.mdpi.com/2076-3417/10/14/4792

Internet

https://www.mdpi.com/2076-3417/10/14/4792

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