Indoleamine 2, 3-dioxygenase (IDO) increases during renal fibrogenesis and its inhibition potentiates TGF-β 1-induced epithelial to mesenchymal transition

Indoleamine 2, 3-dioxygenase (IDO) increases during renal fibrogenesis and its inhibition potentiates TGF-β 1-induced epithelial to mesenchymal transition

Abstract Background Indoleamine 2, 3-dioxygenase (IDO) is an immunomodulatory molecule that has been implicated in several biological processes. Although IDO has been linked with some renal diseases, its role in renal fibrosis is still unclear. Because IDO may be modulated by TGF-β1, a potent fibrog...

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Bibliographic Details
Main Authors: Luiz Henrique Gomes Matheus, Gislene Mendes Simão, Taíssa Altieri Amaral, Rodrigo Barbosa Oliveira Brito, Camila Soares Malta, Yves Silva Teles Matos, Alexandre Chagas Santana, Gabriela Gomes Cardoso Rodrigues, Maria Clara Albejante, Erna Elisabeth Bach, Maria Aparecida Dalboni, Cleber Pinto Camacho, Humberto Dellê
Format: Article
Language:English
Published: BMC 2017-09-01
Series:BMC Nephrology
Subjects:
Indoleamine 2, 3-dioxygenase
1-methyl-D-tryptophan
Renal fibrosis
Epithelial to mesenchymal transition
TGF-β 1
Renal inflammation
Online Access:http://link.springer.com/article/10.1186/s12882-017-0702-7

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http://link.springer.com/article/10.1186/s12882-017-0702-7

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