A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis

A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis

Abstract Background Frequent activation of the co-transcriptional factor YAP is observed in a large number of solid tumors. Activated YAP associates with enhancer loci via TEAD4-DNA-binding protein and stimulates cancer aggressiveness. Although thousands of YAP/TEAD4 binding-sites are annotated, the...

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Main Authors: Li Li, Alejandro P. Ugalde, Colinda L. G. J. Scheele, Sebastian M. Dieter, Remco Nagel, Jin Ma, Abhijeet Pataskar, Gozde Korkmaz, Ran Elkon, Miao-Ping Chien, Li You, Pin-Rui Su, Onno B. Bleijerveld, Maarten Altelaar, Lyubomir Momchev, Zohar Manber, Ruiqi Han, Pieter C. van Breugel, Rui Lopes, Peter ten Dijke, Jacco van Rheenen, Reuven Agami
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Genome Biology
Subjects:
YAP
Enhancer
TRAM2
Proliferation
Migration
Invasion
Online Access:https://doi.org/10.1186/s13059-021-02272-8

Internet

https://doi.org/10.1186/s13059-021-02272-8

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