A Tumor-Specific Super-Enhancer Drives Immune Evasion by Guiding Synchronous Expression of PD-L1 and PD-L2

A Tumor-Specific Super-Enhancer Drives Immune Evasion by Guiding Synchronous Expression of PD-L1 and PD-L2

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Summary: PD-L1 and PD-L2 are important targets for immune checkpoint blockade, but how tumor cells achieve their expression remains to be addressed. Here, we find that PD-L1 and PD-L2 are co-expressed in cancer cell lines and tissues across different cancer types. In breast cancer, MDA-MB-231 and SU...

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Bibliographic Details
Main Authors: Yuanpei Xu, Yingcheng Wu, Siliang Zhang, Panpan Ma, Xinxin Jin, Zhou Wang, Min Yao, Erhao Zhang, Baorui Tao, Yongwei Qin, Hao Chen, Aifen Liu, Miaomiao Chen, Mingbing Xiao, Cuihua Lu, Renfang Mao, Yihui Fan
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719314159

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http://www.sciencedirect.com/science/article/pii/S2211124719314159

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