Patients With <italic toggle="yes">LDLR</italic> and <italic toggle="yes">PCSK9</italic> Gene Variants Experienced Higher Incidence of Cardiovascular Outcomes in Heterozygous Familial Hypercholesterolemia

Patients With <italic toggle="yes">LDLR</italic> and <italic toggle="yes">PCSK9</italic> Gene Variants Experienced Higher Incidence of Cardiovascular Outcomes in Heterozygous Familial Hypercholesterolemia

Background Patients with familial hypercholesterolemia who harbored both low‐density lipoprotein receptor (LDLR) and PCSK9 (proprotein convertase subtilisin/kexin type 9) gene variants exhibit severe phenotype associated with substantially high levels of low‐density lipoprotein cholesterol. In this...

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Bibliographic Details
Main Authors: Takahito Doi, Mika Hori, Mariko Harada‐Shiba, Yu Kataoka, Daisuke Onozuka, Kunihiro Nishimura, Ryo Nishikawa, Kosuke Tsuda, Masatsune Ogura, Cheol Son, Yoshihiro Miyamoto, Teruo Noguchi, Hiroaki Shimokawa, Satoshi Yasuda
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiovascular outcome
familial hypercholesterolemia
LDLR gene
PCSK9 gene
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.120.018263

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https://www.ahajournals.org/doi/10.1161/JAHA.120.018263

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