p53 Loss Mediates Hypersensitivity to ETS Transcription Factor Inhibition Based on PARylation-Mediated Cell Death Induction

p53 Loss Mediates Hypersensitivity to ETS Transcription Factor Inhibition Based on PARylation-Mediated Cell Death Induction

The small-molecule E26 transformation-specific (ETS) factor inhibitor YK-4-279 was developed for therapy of ETS/EWS fusion-driven Ewing’s sarcoma. Here we aimed to identify molecular factors underlying YK-4-279 responsiveness in ETS fusion-negative cancers. Cell viability screenings that deletion of...

Full description

Bibliographic Details
Main Authors: Carina Dinhof, Christine Pirker, Philipp Kroiss, Dominik Kirchhofer, Lisa Gabler, Johannes Gojo, Daniela Lötsch-Gojo, Mirjana Stojanovic, Gerald Timelthaler, Franziska Ferk, Siegfried Knasmüller, Johannes Reisecker, Sabine Spiegl-Kreinecker, Peter Birner, Matthias Preusser, Walter Berger
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
ETS1
p53
ETS factor inhibitor
YK-4-279
PARylation
parthanatos
Online Access:https://www.mdpi.com/2072-6694/12/11/3205

Internet

https://www.mdpi.com/2072-6694/12/11/3205

Similar Items