Distinct roles and actions of protein disulfide isomerase family enzymes in catalysis of nascent-chain disulfide bond formation

Distinct roles and actions of protein disulfide isomerase family enzymes in catalysis of nascent-chain disulfide bond formation

Summary: The mammalian endoplasmic reticulum (ER) harbors more than 20 members of the protein disulfide isomerase (PDI) family that act to maintain proteostasis. Herein, we developed an in vitro system for directly monitoring PDI- or ERp46-catalyzed disulfide bond formation in ribosome-associated na...

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Bibliographic Details
Main Authors: Chihiro Hirayama, Kodai Machida, Kentaro Noi, Tadayoshi Murakawa, Masaki Okumura, Teru Ogura, Hiroaki Imataka, Kenji Inaba
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:iScience
Subjects:
Cell Biology
Molecular Biology
Structural Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221002649

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http://www.sciencedirect.com/science/article/pii/S2589004221002649

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