Vaccination With Recombinant Filamentous fd Phages Against Parasite Infection Requires TLR9 Expression

Vaccination With Recombinant Filamentous fd Phages Against Parasite Infection Requires TLR9 Expression

Recombinant filamentous fd bacteriophages (rfd) expressing antigenic peptides were shown to induce cell-mediated immune responses in the absence of added adjuvant, being a promising delivery system for vaccination. Here, we tested the capacity of rfd phages to protect against infection with the huma...

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Bibliographic Details
Main Authors: João F. Gomes-Neto, Rossella Sartorius, Fábio B. Canto, Thamyres S. Almeida, André A. Dias, Carlos-Henrique D. Barbosa, Guilherme A. Melo, Ana Carolina Oliveira, Pedro-Henrique N. Aguiar, Carlos R. Machado, Herbert L. de Matos Guedes, Marcelo F. Santiago, Alberto Nóbrega, Piergiuseppe De Berardinis, Maria Bellio
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
fd phages
Tlr9
Trypanosoma cruzi
cytotoxic T cell
delivery system
vaccine
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01173/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01173/full

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