Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability

Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability

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Summary: In the absence of a dominant driving mutation other than uniformly present TP53 mutations, deeper understanding of the biology driving ovarian high-grade serous cancer (HGSC) requires analysis at a functional level, including post-translational modifications. Comprehensive proteogenomic and...

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Bibliographic Details
Main Authors: Jason E. McDermott, Osama A. Arshad, Vladislav A. Petyuk, Yi Fu, Marina A. Gritsenko, Therese R. Clauss, Ronald J. Moore, Athena A. Schepmoes, Rui Zhao, Matthew E. Monroe, Michael Schnaubelt, Chia-Feng Tsai, Samuel H. Payne, Chen Huang, Liang-Bo Wang, Steven Foltz, Matthew Wyczalkowski, Yige Wu, Ehwang Song, Molly A. Brewer, Mathangi Thiagarajan, Christopher R. Kinsinger, Ana I. Robles, Emily S. Boja, Henry Rodriguez, Daniel W. Chan, Bing Zhang, Zhen Zhang, Li Ding, Richard D. Smith, Tao Liu, Karin D. Rodland
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Cell Reports Medicine
Subjects:
proteogenomics
ovarian cancer
phosphoproteomics
proteomics
fallopian tube
homologous repair deficiency
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379120300045

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http://www.sciencedirect.com/science/article/pii/S2666379120300045

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