Effect of γ-Cyclodextrin Inclusion Complex on the Absorption of R-α-Lipoic Acid in Rats

Effect of γ-Cyclodextrin Inclusion Complex on the Absorption of R-α-Lipoic Acid in Rats

R-α-lipoic acid (RLA) is an endogenous organic acid, and works as a cofactor for mitochondrial enzymes and as a kind of antioxidant. Inclusion complexes of RLA with α-, β- or γ-cyclodextrins (CD) were prepared and orally administered as a suspension to rats. Among them, RLA/γ-CD showed the highest...

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Bibliographic Details
Main Authors: Ryota Uchida, Kosuke Iwamoto, Suetada Nagayama, Atsushi Miyajima, Hinako Okamoto, Naoko Ikuta, Hiroshi Fukumi, Keiji Terao, Takashi Hirota
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:International Journal of Molecular Sciences
Subjects:
γ-cyclodextrin
inclusion complex
R-α-lipoic acid
pharmacokinetic-profile
absorption
intraduodenal administration
rats
X-ray imaging
Online Access:http://www.mdpi.com/1422-0067/16/5/10105

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http://www.mdpi.com/1422-0067/16/5/10105

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