QSAR and molecular docking based design of some indolyl-3-ethanone-α-thioethers derivatives as Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors

QSAR and molecular docking based design of some indolyl-3-ethanone-α-thioethers derivatives as Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors

Abstract Malaria, a disease caused by one of the world’s fatal parasites Plasmodium falciparum, is responsible for over a million death annually. P. falciparum dihydroorotate dehydrogenase (PfDHODH) is a validated target of this deadly parasite. Quantitative structure–activity relationship and molec...

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Bibliographic Details
Main Authors: Zakari Ya’u Ibrahim, Adamu Uzairu, Gideon Shallangwa, Stephen Abechi
Format: Article
Language:English
Published: Springer 2020-06-01
Series:SN Applied Sciences
Subjects:
QSAR
Molecular docking
Molecular design
Antimalarial
Indolyl-3-ethanone-α-thioethers
Descriptors
Online Access:https://doi.org/10.1007/s42452-020-2955-1

Internet

https://doi.org/10.1007/s42452-020-2955-1

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