Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes NaV1.9, NaV1.7 and NaV1.1

Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes NaV1.9, NaV1.7 and NaV1.1

Ciguatoxins (CTXs) are marine toxins that cause ciguatera fish poisoning, a debilitating disease dominated by sensory and neurological disturbances that include cold allodynia and various painful symptoms as well as long-lasting pruritus. Although CTXs are known as the most potent mammalian sodium c...

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Bibliographic Details
Main Authors: Filip Touska, Simon Sattler, Philipp Malsch, Richard J. Lewis, Peter W. Reeh, Katharina Zimmermann
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Marine Drugs
Subjects:
voltage-gated calcium channels
calcitonin-gene related peptide
tetrodotoxin
TTX
P-CTX-1
TRPA1
TRPC5
TRPM8
ciguatera
neuropathic pain
neurogenic inflammation
Online Access:https://www.mdpi.com/1660-3397/15/9/269

Internet

https://www.mdpi.com/1660-3397/15/9/269

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