Creatine Increases Survival and Delays Motor Symptoms in a Transgenic Animal Model of Huntington's Disease

Creatine Increases Survival and Delays Motor Symptoms in a Transgenic Animal Model of Huntington's Disease

There is substantial evidence for bioenergetic defects in Huntington's disease (HD). Creatine administration increases brain phosphocreatine levels and it stabilizes the mitochondrial permeability transition. We examined the effects of creatine administration in a transgenic mouse model of HD p...

Full description

Bibliographic Details
Main Authors: Ole A. Andreassen, Alpaslan Dedeoglu, Robert J. Ferrante, Bruce G. Jenkins, Kimberly L. Ferrante, Melissa Thomas, Avi Friedlich, Susan E. Browne, Gabriele Schilling, David R. Borchelt, Steven M. Hersch, Christopher A. Ross, M.Flint Beal
Format: Article
Language:English
Published: Elsevier 2001-06-01
Series:Neurobiology of Disease
Subjects:
Huntington's
transgenic
creatine
N-acetylaspartate
diabetes
NMR spectroscopy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996101904061

Internet

http://www.sciencedirect.com/science/article/pii/S0969996101904061

Similar Items