CRISPR/Cas9-Mediated Foxp1 Silencing Restores Immune Surveillance in an Immunocompetent A20 Lymphoma Model

CRISPR/Cas9-Mediated Foxp1 Silencing Restores Immune Surveillance in an Immunocompetent A20 Lymphoma Model

The interaction of lymphoma cells with their microenvironment has an important role in disease pathogenesis and is being actively pursued therapeutically using immunomodulatory drugs, including immune checkpoint inhibitors. Diffuse large B-cell lymphoma (DLBCL) is an aggressive high-grade disease th...

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Bibliographic Details
Main Authors: Suet Ling Felce, Amanda P. Anderson, Shaun Maguire, Duncan M. Gascoyne, Richard N. Armstrong, Kah Keng Wong, Demin Li, Alison H. Banham
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Oncology
Subjects:
lymphoma
MHC class II
diffuse large B-cell lymphoma
FOXP1
immune response
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00448/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00448/full

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