Synthesis of adenosine analogues with indole moiety as human adenosine A3 receptor ligands

Adenosine is an endogenous modulator exerting its functions through the activation of four adenosine receptor (AR) subtypes, termed A1, A2A, A2B and A3, which belong to the G-protein-coupled receptor superfamily. The human A3AR (hA3AR) subtype is implicated in several cytoprotective functions. There...

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Bibliographic Details
Main Authors: Yan Xia, Xiliang Zheng, Erkang Wang, Dongfeng Li, Ruibin Hou, Jin Wang
Format: Article
Language:English
Published: The Royal Society 2018-01-01
Series:Royal Society Open Science
Subjects:
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.171596