Developmental profile of the aberrant dopamine D2 receptor response in striatal cholinergic interneurons in DYT1 dystonia.

Developmental profile of the aberrant dopamine D2 receptor response in striatal cholinergic interneurons in DYT1 dystonia.

DYT1 dystonia, a severe form of genetically determined human dystonia, exhibits reduced penetrance among carriers and begins usually during adolescence. The reasons for such age dependence and variability remain unclear.We characterized the alterations in D2 dopamine receptor (D2R) signalling in str...

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Bibliographic Details
Main Authors: Giuseppe Sciamanna, Annalisa Tassone, Giuseppina Martella, Georgia Mandolesi, Francesca Puglisi, Dario Cuomo, Grazia Madeo, Giulia Ponterio, David George Standaert, Paola Bonsi, Antonio Pisani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3166312?pdf=render

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http://europepmc.org/articles/PMC3166312?pdf=render

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