Rewiring the Epigenetic Networks in MLL-Rearranged Leukemias: Epigenetic Dysregulation and Pharmacological Interventions

Rewiring the Epigenetic Networks in MLL-Rearranged Leukemias: Epigenetic Dysregulation and Pharmacological Interventions

Leukemias driven by chromosomal translocation of the mixed-lineage leukemia gene (MLL or KMT2A) are highly prevalent in pediatric oncology. The poor survival rate and lack of an effective targeted therapy for patients with MLL-rearranged (MLL-r) leukemias emphasize an urgent need for improved knowle...

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Bibliographic Details
Main Authors: Anthony K. N. Chan, Chun-Wei Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
MLL-rearranged
leukemias
epigenetics
MLL
chromatin
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00081/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2019.00081/full

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