Cell Line Derived Xenograft Mouse Models Are a Suitable in vivo Model for Studying Tumor Budding in Colorectal Cancer

Cell Line Derived Xenograft Mouse Models Are a Suitable in vivo Model for Studying Tumor Budding in Colorectal Cancer

Tumor budding (TB) is an important prognostic parameter in colorectal cancer (CRC) and associated with metastasis. However, the mechanisms of TB have not been fully elucidated and a major limitation is the absence of in vivo models. Here, we determine the suitability of human cell line derived xenog...

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Bibliographic Details
Main Authors: Laurent M. C. Georges, Olivier De Wever, José A. Galván, Heather Dawson, Alessandro Lugli, Pieter Demetter, Inti Zlobec
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Medicine
Subjects:
colorectal cancer
tumor budding
mouse model
xenograft
cell line
epithelial-mesenchymal transition
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2019.00139/full

Internet

https://www.frontiersin.org/article/10.3389/fmed.2019.00139/full

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