Clinical and molecular characterization of virus-positive and virus-negative Merkel cell carcinoma

Clinical and molecular characterization of virus-positive and virus-negative Merkel cell carcinoma

Abstract Background Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine carcinoma of the skin caused by either the integration of Merkel cell polyomavirus (MCPyV) and expression of viral T antigens or by ultraviolet-induced damage to the tumor genome from excessive sunlight exposure. A...

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Bibliographic Details
Main Authors: Gabriel J. Starrett, Manisha Thakuria, Tianqi Chen, Christina Marcelus, Jingwei Cheng, Jason Nomburg, Aaron R. Thorner, Michael K. Slevin, Winslow Powers, Robert T. Burns, Caitlin Perry, Adriano Piris, Frank C. Kuo, Guilherme Rabinowits, Anita Giobbie-Hurder, Laura E. MacConaill, James A. DeCaprio
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Genome Medicine
Subjects:
Cancer genomics
Polyomavirus
Integration
Somatic variants
Mutagenesis
Online Access:http://link.springer.com/article/10.1186/s13073-020-00727-4

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http://link.springer.com/article/10.1186/s13073-020-00727-4

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