Congenital B-lymphoblastic leukemia with a cryptic MLL rearrangement and post-treatment evolution to mixed phenotype acute leukemia

Congenital leukemia is a rare event with a poor prognosis. We report a case of congenital leukemia with a cryptic rearrangement of MLL demonstrable only with RT-PCR. Interestingly, with treatment, the patient showed lineage plasticity of the leukemia with the development of monocytic lineage blasts...

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Bibliographic Details
Main Authors: Elizabeth Moschiano, Gordana Raca, Cecilia Fu, Paul K. Pattengale, Mathew J. Oberley
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Leukemia Research Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S221304891630005X